| Description | DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM). |
| In vivo | In a rat model of obesity and impaired glucose tolerance, DPP-IV-IN-1 (0.1 and 0.3 mg/kg, p.o.) reduces the increase in plasma glucose beginning 30 min after glucose loading and significantly suppresses hyperglycemia (0.3 mg/kg). The effect is based on its inhibitory effect on plasma DPP-IV activity. |
| molecular weight | 243.28 |
| Molecular formula | C11H18FN3O2 |
| CAS | 625110-37-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Fukushima H, et al. Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. Bioorg Med Chem. 2008 Apr 1;16(7):4093-106. |