| Description | DPC-963 is a RNA-directed DNA polymerase inhibitor. |
| Synonyms | DMP 963, DMP963, DMP-963, DPC 963, DPC963 |
| molecular weight | 316.23 |
| Molecular formula | C14H9F5N2O |
| CAS | 214287-90-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Li S, Ma JA. Core-structure-inspired asymmetric addition reactions: enantioselective synthesis of dihydrobenzoxazinone- and dihydroquinazolinone-based anti-HIV agents. Chem Soc Rev. 2015 Nov 7;44(21):7439-48. doi: 10.1039/c5cs00342c. Review. PubMed PMID: 26177889. 2. Badawy SI, Lee TJ, Menning MM. Effect of drug substance particle size on the characteristics of granulation manufactured in a high-shear mixer. AAPS PharmSciTech. 2000 Nov 17;1(4):E33. PubMed PMID: 14727898; PubMed Central PMCID: PMC2750457. 3. Xie M, Ziemba TM, Maurin MB. Sublimation characterization and vapor pressure estimation of an HIV nonnucleoside reverse transcriptase inhibitor using thermogravimetric analysis. AAPS PharmSciTech. 2003;4(2):E23. PubMed PMID: 12916905; PubMed Central PMCID: PMC2750601. 4. Chen H, Chen W, Gan LS, Mutlib AE. Metabolism of (S)-5,6-difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro-2(1H)-quinazolinone, a non-nucleoside reverse transcriptase inhibitor, in human liver microsomes. Metabolic activation and enzyme kinetics. Drug Metab Dispos. 2003 Jan;31(1):122-32. PubMed PMID: 12485961. |