| Description | DOPE (DOPE) is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery. |
| In vitro | 每个siRNA被封装在LNP中（阳离子脂质-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 摩尔百分比）。LNP的中性脂质为DOPE，它对巨噬细胞和树突状细胞（DCs）展现出敲击下（KD）效果，并且包含DOPE的脂质体显示出融合性。LNP/siRNA显著抑制巨噬细胞和DCs上CD45蛋白的表达，抑制率为30%，但对单核细胞、中性粒细胞、浆细胞性DCs或B细胞无影响。 |
| Target activity | Helper lipid for liposome: |
| Synonyms | 1,2-二油酰-SN-甘油-3-磷酰乙醇胺 |
| molecular weight | 744.03 |
| Molecular formula | C41H78NO8P |
| CAS | 4004-05-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: ＜1 mg/mL (insoluble or slightly soluble), Sonication is recommended. |
| References | 1. Uemura Y, et al. The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells.Pharm Dev Technol. 2019 Mar;24(3):263-268. |