| Description | Donafenib (Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively). |
| Synonyms | Sorafenib (D3), Bay 43-9006 (D3), Sorafenib-d3 |
| molecular weight | 467.84 |
| Molecular formula | C21H13ClD3F3N4O3 |
| CAS | 1130115-44-4 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 90 mg/mL ( 192.4 mM), Sonication is recommended. |
| References | 1. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109. |