Docosahexaenoic Acid methyl ester Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Docosahexaenoic Acid methyl ester (all cis-DHA methyl ester) is a methylated docosahexaenoic acid analog that can be inserted into membrane phospholipids without being oxidized or hydrolyzed.
In vitro	在施用Docosahexaenoic Acid methyl ester(DHA-Me)后，与基线相比，尖波(SPW)的发生率似乎有所下降。在没有Docosahexaenoic Acid methyl ester(DHA)的情况下，当牛血清白蛋白(BSA)暴露于Fe2+和抗坏血酸(AsA)的混合功能氧化系统中时，不会产生新的蛋白带。然而，当BSA与DHA孵育仅24小时时，观察到高分子量蛋白带。BSA与1.0 mM DHA孵育导致蛋白质羰基含量显著增加，而添加氧自由基清除剂则导致蛋白质羰基含量显著降低。
Synonyms	二十二六烯酸甲酯, Methyl docosahexaenoate, all cis-DHA methyl ester
molecular weight	342.51
Molecular formula	C23H34O2
CAS	2566-90-7
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	Ethanol: 100 mg/mL (291.96 mM), Sonication is recommended. DMSO: 25 mg/mL (72.99 mM), Sonication is recommended.
References	1. Taha AY, et al. Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo. Brain Res. 2013 Nov 6;1537:9-17. 2. Liu W, et al. Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products. Biochim Biophys Acta. 2007 Feb;1774(2):258-66.

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