| Description | DO1 (Disperse Orange 1) is an anti-amyloid agent which potently delays both seeded and non-seeded Aβ42 polymerization at substoichiometric concentrations |
| In vivo | DO1 干扰合成 Aβ42 肽形成的纤维聚集体，并减少来自 AD 转基因小鼠大脑提取物中的 Aβ 聚集体的播种活性。DO1 还减少了 5xFAD 转基因小鼠大脑中弥漫性 Aβ 斑块的大小和数量，并降低了与神经炎症相关的基因表达变化[1]。 |
| Synonyms | 分散橙1, Disperse Orange 1 |
| molecular weight | 318.33 |
| Molecular formula | C18H14N4O2 |
| CAS | 2581-69-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 3.18 mg/mL (10 mM) |
| References | 1. Boeddrich A, Babila JT, Wiglenda T,et al.The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice[J].Cell Chem Biol. 2019 Jan 17 ;26(1):109-120.e7. |