| Description | DO-264 is an inhibitor of autohydrolase structural domain 12 (ABHD12) (IC50: 11 nM) and an inhibitor of cellular LysoPS degradation that enhances LPS-induced phagocytosis. |
| In vitro | DO-264 能够提高初级人类巨噬细胞的溶酶体磷脂酰丝氨酸(lyso-PS)和20:4 PS含量[1]。 |
| In vivo | 用 DO-264 处理的小鼠显示出脑溶解 -PS 和 20：4PS 含量的剂量依赖性增加，其质量上与 ABHD12(-/-)小鼠中观察到的变化相似。同时 ABHD12(−/−) 和 DO-264 处理的小鼠在感染淋巴细胞性脑膜炎病毒(LCMV)13型克隆后显示出加重的免疫病理学表现，导致严重的肺部炎症损伤、化学因子产生增加，并且在某些情况下导致死亡[1]。 |
| Target activity | ABHD12:11 nM |
| molecular weight | 558.4 |
| Molecular formula | C23H20Cl2F3N5O2S |
| CAS | 2301866-59-9 |
| Storage | store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 80 mg/mL (143.27 mM) |
| References | 1. Ogasawara D, et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol. 2018 Dec;14(12):1099-1108. |