| Description | DNL343, a brain-penetrating eIF2B (eukaryotic initiation factor 2B) activator, suppresses the abnormal integrated stress response (ISR). By inhibiting ISR activity in the central nervous system (CNS), DNL343 ameliorates neurodegeneration and neuroinflammation. Additionally, it protects against motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice and demonstrates inhibitory potential for vanishing white matter disease (VWMD) characterized by eIF2B LOF and persistent ISR activation [1]. |
| molecular weight | 457.83 |
| Molecular formula | C20H19ClF3N3O4 |
| CAS | 2278265-85-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |