| Description | DL-threo dihydrosphingosine is a cell-permeable inhibitor of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. DL-threo dihydrosphingosine may be usefully employed to block smooth muscle cell proliferation. |
| Synonyms | DL-Safingol, DTD, DL threo dihydrosphingosine |
| molecular weight | 301.51 |
| Molecular formula | C18H39NO2 |
| CAS | 2304-75-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Tolan D, Conway AM, Steele L, Pyne S, Pyne NJ. The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. Br J Pharmacol. 1996 Sep;119(2):185-6. PubMed PMID: 8886394; PubMed Central PMCID: PMC1915874. 2. Meyer SG, de Groot H. Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling. Biochim Biophys Acta. 2003 Dec 7;1643(1-3):1-4. PubMed PMID: 14654222. 3. Ma Y, She X, Yang S. Sphingosine-1-phosphate (S1P) mediates darkness-induced stomatal closure through raising cytosol pH and hydrogen peroxide (H₂O₂) levels in guard cells in Vicia faba. Sci China Life Sci. 2012 Nov;55(11):974-83. doi: 10.1007/s11427-012-4386-8. Epub 2012 Oct 22. PubMed PMID: 23090064. 4. Buehrer BM, Bell RM. Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways. J Biol Chem. 1992 Feb 15;267(5):3154-9. PubMed PMID: 1310683. |