| Description | Disulfamide is an orally active carbonic anhydrase inhibitor with an IC50 value of 0.07 μM. Disulfamide has a diuretic effect by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal convoluted tubules. |
| In vivo | With a single intraperitoneal injection of 200 mg/kg, disulfamide demonstrates potential blood glucose-raising properties in male Wistar rats[2]. |
| Target activity | CA:0.07 μM |
| molecular weight | 284.74 |
| Molecular formula | C7H9ClN2O4S2 |
| CAS | 671-88-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (158.04 mM) |
| References | 1. CT Supuran, et al. Carbonic anhydrase inhibitors: Synthesis and inhibitory properties of 1,3,4-thiadiazole-2,5-bissulfonamide. European Journal of Medicinal Chemistry,Volume 31, Issue 11, 1996, Pages 843-846. 2. J M Foy, et al. Acute diuretic induced hyperglycaemia in rats. Life Sci. 1967 May 1;6(9):897-902. |