| Description | Disoxaril (BRN 3626820, WIN 51711) is an anti-picornavirus agent that inhibits enterovirus replication by binding to a hydrophobic bag within the VP1 coat protein, thereby stabilizing virions and preventing their uncoating. When used in combination with Ambioxime and Bioxazole, there was a significant synergistic inhibition of poliovirus type 1 replication in FL cells. |
| Synonyms | BRN 3626820, WIN51711, WIN-51711, BRN-3626820, WIN 51711, WIN-51,711 |
| molecular weight | 342.43 |
| Molecular formula | C20H26N2O3 |
| CAS | 87495-31-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Nikolova I, Galabov AS, Petkova R, Chakarov S, Atanasov B. Disoxaril mutants of Coxsackievirus B1: phenotypic characteristics and analysis of the target VP1 gene. Z Naturforsch C. 2011 Nov-Dec;66(11-12):627-36. PubMed PMID: 22351989. 2. Ventura CA, Giannone I, Musumeci T, Pignatello R, Ragni L, Landolfi C, Milanese C, Paolino D, Puglisi G. Physico-chemical characterization of disoxaril-dimethyl-beta-cyclodextrin inclusion complex and in vitro permeation studies. Eur J Med Chem. 2006 Feb;41(2):233-40. Epub 2006 Jan 4. PubMed PMID: 16387393. 3. Nikolova I, Galabov AS. Development of resistance to disoxaril in Coxsackie B1 virus-infected newborn mice. Antiviral Res. 2003 Sep;60(1):35-40. PubMed PMID: 14516919. 4. Nikolaeva L, Galabov AS. Antiviral effect of the combination of enviroxime and disoxaril on coxsackievirus B1 infection. Acta Virol. 2000 Apr;44(2):73-8. PubMed PMID: 10989697. |