| Description | Disitertide (P144) is an inhibitor of TGF-β1. |
| In vitro | Aurora B inhibitor 1 also inhibits JAK3 and JAK2 with Kis of <0.25 μM and <0.10 μM, respectively[1]. |
| In vivo | In the rat model of long-term exposure to CCl4, low-dose Disitertide (P144) treatment can significantly inhibit HSC activation and significantly reduce liver fibrosis. |
| Synonyms | P144 |
| molecular weight | 1580.84 |
| Molecular formula | C68H109N17O22S2 |
| CAS | 272105-42-7 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 200 mg/mL (126.52 mM) |
| References | 1. Ezquerro IJ et al. A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine. 2003 Apr;22(1-2):12-20. |