| Description | Diphenylcyclopropenone (DPCP) is a topical drug used to treat alopecia areata, alopecia totalis, and refractory warts. Diphencyprone acts as a local stimulator that triggers an immune response against the action of autoreactive cells. |
| Synonyms | DPCP, Diphencyprone, 二苯基环丙烯酮 |
| molecular weight | 206.24 |
| Molecular formula | C15H10O |
| CAS | 886-38-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 88 mg/mL (426.69 mM) H2O: Insoluble |
| References | 1. Moncrieff M, Fadhil M, Garioch J. Topical diphencyprone for the treatment of locoregional intralymphatic melanoma metastases (LIMMs) of the skin. The 5-Year Norwich experience. Br J Dermatol. 2015 Nov 24. 2. Bulock KG, Cardia JP, Pavco PA, Levis WR. Diphencyprone Treatment of Alopecia Areata: Postulated Mechanism of Action and Prospects for Therapeutic Synergy with RNA Interference. J Investig Dermatol Symp Proc. 2015 Nov;17(2):16-8. 3. Moncrieff M, Fadhil M, Garioch J. Topical diphencyprone for the treatment of locoregional intralymphatic melanoma metastases (LIMMs) of the skin. The 5-Year Norwich experience. Br J Dermatol. 2015 Nov 24. doi: 10.1111/bjd.14314. [Epub ahead of print] PubMed PMID: 26598951. 4. Lamb RC, Young D, Holmes S. Retrospective review of diphencyprone in the treatment of alopecia areata. Clin Exp Dermatol. 2015 Dec 1. |