| Description | Dihydrotachysterol (HSDB 3314) is a vitamin D analog.Dihydrotachysterol has been used to study hypocalcemic hypoparathyroidism after surgical removal of the parathyroid glands and growth impairment in children with chronic renal insufficiency. |
| In vitro | 在五只混合品种的年轻到中年猫的动物模型中，Dihydrotachysterol（0.03-0.08 mg/kg/d，持续 2-3 天。最终剂量范围为0.004-0.04 mg/kg/d；口服给药）可用于治疗甲状旁腺功能减退症[2]。 |
| Synonyms | HSDB 3314, Parterol, Hytakerol, HSDB3314, HSDB-3314 |
| molecular weight | 398.66 |
| Molecular formula | C28H46O |
| CAS | 67-96-9 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 15 mg/mL (37.63 mM), Sonication is recommended. H2O: Insoluble |
| References | 1. I Quack, et al. Dihydrotachysterol therapy for hypoparathyroidism: consequences of inadequate monitoring. Five cases and a review. Exp Clin Endocrinol Diabetes. 2005 Jul;113(7):376-80. 2. M E Peterson, et al. Idiopathic hypoparathyroidism in five cats. J Vet Intern Med. Jan-Feb 1991;5(1):47-51. 3. Voigts AL, Felsenfeld AJ, Llach F. The effects of calciferol and its metabolites on patients with chronic renal failure. I. Calciferol, dihydrotachysterol, and calcifediol. Arch Intern Med. 1983 May;143(5):960-3. 4. Pierides AM. Pharmacology and therapeutic use of vitamin D and its analogues. Drugs. 1981 Apr;21(4):241-56. |