| Description | DiFMUP (6,8-Difluoro-4-methylumbelliferyl phosphate) inhibits protein tyrosine phosphatases (PTPs) and can be used to assay threonine phosphatase activity. |
| Synonyms | 6,8-Difluoro-4-methylumbelliferyl phosphate |
| molecular weight | 292.13 |
| Molecular formula | C10H7F2O6P |
| CAS | 214491-43-7 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (102.69 mM), Sonication is recommended. |
| References | 1. Gee KR, et al. Fluorogenic substrates based on fluorinated umbelliferones for continuous assays of phosphatases and beta-galactosidases. Anal Biochem. 1999 Aug 15;273(1):41-8. 2. Welte S, et al. 6,8-Difluoro-4-methylumbiliferyl phosphate: a fluorogenic substrate for protein tyrosine phosphatases. Anal Biochem. 2005 Mar 1;338(1):32-8. 3. Gade TP, et al. Imaging of alkaline phosphatase activity in bone tissue. PLoS One. 2011;6(7):e22608. 4. Lade DM,et al. Design and synthesis of improved active-site SHP2 inhibitors with anti-breast cancer cell effects. Eur J Med Chem. 2023 Feb 5;247:115017. |