| Description | Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria. |
| In vitro | Dicloxacillin Sodium is a narrow-spectrum β-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible Gram-positive bacteria. It is active against beta-lactamase-producing organisms such as Staphylococcus aureus, which would otherwise be resistant to most penicillins.[1] Like other β-lactam antibiotics, dicloxacillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria. Dicloxacillin is insensitive to beta-lactamase (also known as penicillinase) enzymes secreted by many penicillin-resistant bacteria. The presence of the isoxazolyl group on the side-chain of the penicillin nucleus facilitates the β-lactamase resistance, since they are relatively intolerant of side-chain steric hindrance. Thus, it is able to bind to penicillin-binding proteins (PBPs) and inhibit peptidoglycan crosslinking, but is not bound by or inactivated by β-lactamases. [2] |
| Synonyms | Veracillin, 双氯西林, BRL1702 Sodium, BRL1702, Sodium dicloxacillin, 双氯西林钠 |
| molecular weight | 510.32 |
| Molecular formula | C19H17Cl2N3O5S·H2O·Na |
| CAS | 343-55-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 93 mg/mL (182.2 mM) H2O: 92 mg/mL (180.3 mM) Ethanol: 21 mg/mL (41.2 mM) |
| References | 1. Quijano R, et al. Proc Soc Exp Biol Med. 1979, 162(3), 442-444. 2. Nielsen SL, et al. J Antimicrob Chemother, 1998, 42(2), 221-226. |