| Description | DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth. This compound effectively suppresses methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 with an IC50 of 15.6 ng/mL in mouse models of systemic and thigh infections [1]. |
| molecular weight | 346.41 |
| Molecular formula | C18H14N6S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |