| Description | Dexoxadrol Hydrochloride, a dissociative anesthetic, has been found to be an NMDA antagonist. |
| Synonyms | NSC 526062, U 22558 A, d-Dioxadrol hydrochloride, NSC-526062, Relane |
| molecular weight | 345.86 |
| Molecular formula | C20H24ClNO2 |
| CAS | 631-06-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Utech T, Köhler J, Wünsch B. Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists. Eur J Med Chem. 2011 Jun;46(6):2157-69. doi: 10.1016/j.ejmech.2011.02.070. Epub 2011 Mar 5. PubMed PMID: 21444132. 2. Banerjee A, Schepmann D, Köhler J, Würthwein EU, Wünsch B. Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists. Bioorg Med Chem. 2010 Nov 15;18(22):7855-67. doi: 10.1016/j.bmc.2010.09.047. Epub 2010 Sep 25. PubMed PMID: 20965735. 3. Sax M, Ebert K, Schepmann D, Wibbeling B, Wünsch B. Synthesis and NMDA-receptor affinity of 4-oxo-dexoxadrol derivatives. Bioorg Med Chem. 2006 Sep 1;14(17):5955-62. Epub 2006 Jun 5. PubMed PMID: 16750371. 4. Sax M, Wünsch B. Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity. Curr Top Med Chem. 2006;6(7):723-32. Review. PubMed PMID: 16719812. |