| Description | 1. Desmethoxyyangonin (5,6-Dehydrokavain) protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydromethysticin and Desmethoxy yangonin involves transcription activation, probably through a PXR-independent or PXR-involved indirect mechanism. |
| Synonyms | Desmethoxy yangonin, 去甲氧基醉椒素, Demethoxyyangonin, 5,6-Dehydrokavain |
| molecular weight | 228.24 |
| Molecular formula | C14H12O3 |
| CAS | 15345-89-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (197.15 mM) |
| References | 1. Ma Y , Sachdeva K , Liu J , et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23[J]. Drug Metabolism & Disposition the Biological Fate of Chemicals, 2004, 32(11):1317. |