| Description | Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB. |
| Target activity | DENV-2:9.23 μM(EC50), DENV-3:7.08 μM(EC50), HIV-1 (IIIB):0.1512 μM(EC50), DENV-4:8.91 μΜ(EC50), DENV-1:1.47 μM |
| molecular weight | 478.99 |
| Molecular formula | C23H25ClF2N4OS |
| CAS | 2375781-06-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 12 mg/mL (25.05 mM) |
| References | 1. Rui RM, et al. C6-structural optimizations of 2-aryl-1H-pyrazole-S-DABOs: From anti-HIV to anti-DENV activity. Bioorg Chem. 2022;119:105494. |