| Description | (-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin. |
| In vitro | Denudatin B 以浓度依赖性方式抑制因血小板活化因子 (PAF) 导致的洗涤兔血小板的聚集和 ATP 释放。较高浓度的 Denudatin B（大于 50 微克/毫升）能抑制由 ADP、胶原蛋白、花生四烯酸和凝血酶引起的血小板聚集和 ATP 释放。Denudatin B 抑制由凝血酶引起的细胞内钙浓度升高[1]。 |
| Synonyms | Denudatin B |
| molecular weight | 356.41 |
| Molecular formula | C21H24O5 |
| CAS | 87402-88-8 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Teng CM, et al. Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. Thromb Res. 1990 Jul 1;59(1):121-30. 2. Yu SM, et al. Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. Eur J Pharmacol. 1990 Oct 2;187(1):39-47. |