| Description | 7-Demethylsuberosin (7-demethylsuberosin) is a coumarin compound isolated from Angelica gigas Nakai,and has anti-inflammatory activity,and exhibited inhibitory effects on PGE2 production with the IC50 values of 9.42 μM. |
| In vitro | 7-demethylsuberosin was evaluated for their inhibitory activity on LPS-induced NO and prostaglandin E2 (PGE2) productions in RAW 264.7 cells.?7-demethylsuberosin?exhibited high inhibitory effects on PGE2 production with the IC50 values of 9.42, 7.51, and 6.49 μM, respectively[1]. |
| Target activity | PGE2:9.42μM |
| Synonyms | 7-去甲基软木花椒素, 7-demethylsuberosin |
| molecular weight | 230.26 |
| Molecular formula | C14H14O3 |
| CAS | 21422-04-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (238.86 mM) |
| References | 1. Kim HJ, Kim HM, Ryu B,et al.Constituents of PG201 (Layla(®)), a multi-component phytopharmaceutical, with inhibitory activity on LPS-induced nitric oxide and prostaglandin E2 productions in macrophages[J].Arch Pharm Res. 2016 Feb;39(2):231-239. 2. Lacroix D , Prado S , Kamoga D , et al. Structure and in Vitro Antiparasitic Activity of Constituents of Citropsis articulata Root Bark[J]. Journal of Natural Products, 2011, 74(10):2286-2289. |