| Description | Demethylisoencecalin (6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran) has anti-hyperglycemic activity. |
| In vitro | Demethylisoencecalin (1) 及 caleins A (4) 和 C (5) (3.16–31.6 mg/kg, p.o.) 作为 Calea ternifolia 水煎液的主要成分，在正常及 nicotinamide/streptozotocin (NA/STZ, 40/100 mg/kg) 诱导的高血糖小鼠中管理后餐血糖水平，并在口服蔗糖耐受测试 (OSTT, 3 g/kg) 中显示出效果，与 acarbose (5 mg/kg) 相比具有可比性。在分离 1、4 和 5 的过程中，还发现了此植物之前未报道的四个额外代谢产物，即 6-acetyl-5-hydroxy-2-methyl-2-hydroxymethyl-2H-chromene (3)、herniarin (6)、scoparone (7) 和 4′,7-dimethylapigenin (8)。此外，calein C (5) 的结构通过 X 光分析得到确认。该物种精油的药理学评价 (31.6–316.2 mg/kg, p.o.) 也在 OSTT 中显著降低了血糖水平。 |
| Synonyms | 6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran |
| molecular weight | 218.25 |
| Molecular formula | C13H14O3 |
| CAS | 24672-84-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 60 mg/ml (274.91 mM) |
| References | 1. EscandónRivera, Sonia, PérezVásquez,等. Molecules, Vol. 22, Pages 289: Anti-Hyperglycemic Activity of Major Compounds from Calea ternifolia. 2017. |