| Description | Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. |
| In vitro | Dehydro nifedipine 在PC-12细胞中抑制葡萄糖吸收，其半抑制浓度(IC50)值为130 μM[1]。 |
| Target activity | Glucose uptake:130 μM |
| Synonyms | BAY-b 4759 |
| molecular weight | 344.32 |
| Molecular formula | C17H16N2O6 |
| CAS | 67035-22-7 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: 2.7 mg/mL (7.8 mM) DMSO: 27.0 mg/mL (78.5 mM) DMF: 30 mg/mL DMSO:PBS (pH 7.2) (1:10): 0.1 mg/mL |
| References | 1. Shimada T, et al. Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proc Natl Acad Sci U S A. 1989;86(2):462-465. |