| Description | Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant. |
| Synonyms | RO4995819 |
| molecular weight | 447.34 |
| Molecular formula | C21H11F6N5 |
| CAS | 911115-16-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 230 mg/mL (514.15 mM), Sonication is recommended. |
| References | 1. Wilkinson ST, et al. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems. Drug Discov Today. 2019 Feb;24(2):606-615. |