| Description | Decaethylene glycol dodecyl ether, a PEG-based PROTAC linker, finds utility in PROTAC synthesis. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| Synonyms | PEG10-dodecyl |
| molecular weight | 626.869 |
| Molecular formula | C32H66O11 |
| CAS | 618113-48-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |