| Description | DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9. |
| In vitro | DBPR108 在DPP8、DPP9、FAP和DPP-II上展现出超过3000倍的选择性。 |
| In vivo | DBPR108作为2型糖尿病潜在化合物，是一种强效、选择性、长效且安全的DPP-IV抑制剂。其体内效果，包括抑制血浆DPP-IV活性和抑制血糖升高，也得到了证明。 |
| molecular weight | 324.39 |
| Molecular formula | C16H25FN4O2 |
| CAS | 1186426-66-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: ≥ 25 mg/mL (77.07 mM) |
| References | 1. Yeh TK, et al. (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2010 Jun |