| Description | DBCO-PEG4-Biotin (ADIBO-NH-PEG2-Biotin) is an azadibenzocyclooctyne-biotin derivative containing a biotin moiety and 4 PEGs.DBCO-PEG4-Biotin is a versatile biotinylation reagent that introduces a portion of biotin into an azide-labelled biomolecule via a copper-free catalytic alkyl azide reaction (SPAAC). azide-labelled biomolecules via a copper-free catalytic alkyl azide reaction (SPAAC). |
| In vitro | The alkyne group can react with azide moiety in copper-free Click Chemistry reaction. Which to form a stable triazole linkage.[1] |
| Synonyms | ADIBO-NH-PEG2-Biotin |
| molecular weight | 749.92 |
| Molecular formula | C39H51N5O8S |
| CAS | 1255942-07-4 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 74.99 mg/mL (100 mM), Sonication is recommended. |
| References | 1. Hammink R, et al. Affinity-Based Purification of Polyisocyanopeptide Bioconjugates. Bioconjug Chem. 2017 Oct 18;28(10):2560-2568. |