| Description | DBCO-mPEG (MW 5kDa) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
| In vitro | PROTACs由连接器连接的两种不同配体组成，其中一个配体与E3泛素连接酶结合，另一个配体靶向特定的感兴趣蛋白。这些分子利用细胞内的泛素-蛋白酶体系统，实现目标蛋白的选择性降解。[1] |
| molecular weight | 5kDa |
| Storage | store at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL |
| References | 1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |