| Description | DBCO-C2-SulfoNHS ester is an alkyl/ether-based linker commonly employed for the synthesis of PROTACs, a class of compounds that induce targeted protein degradation. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] |
| Synonyms | DBCO-C2-SulfoNHS ester |
| molecular weight | 482.46 |
| Molecular formula | C23H18N2O8S |
| CAS | 1803279-86-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |