| Description | DB772 is a broad-spectrum antiviral activity that inhibits Bovine Viral Diarrhea Virus (BVDV), prion activity, Border Disease Virus (BDV), HoBi Virus, Forked Horn Virus and Bungowannah Virus. |
| In vitro | 在人端粒酶免疫化的（hTERT）羊小胶质细胞系的 PrPSc 阳性和阴性细胞中，DB772（1 μM；持续 4 天）显示对细胞存活率无显著影响，细胞存活率为 96.4%[3]。 |
| Synonyms | DB 772, DB-772 |
| molecular weight | 401.29 |
| Molecular formula | C20H18Cl2N4O |
| CAS | 1451058-50-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. James B Stanton, et al. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7(11):e51173. 2. Benjamin W Newcomer, et al. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Antiviral Res. 2012 Nov;96(2):127-9. 3. Kelcey D Dinkel, et al. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5467-82. 4. Stanton JB, Schneider DA, Dinkel KD, Balmer BF, Baszler TV, Mathison BA, Boykin DW, Kumar A. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7(11):e51173. doi: 10.1371/journal.pone.0051173. Epub 2012 Nov 30. Erratum in: PLoS One. 2015;10(3):e0119084. PubMed PMID: 23226483; PubMed Central PMCID: PMC3511409. |