| Description | Darunavir (TMC114) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS. |
| In vivo | Vipadenant (0.3-30 mg/kg) 能够产生剂量依赖性的减少僵直。在为期19天的给药方案中，Vipadenant (10 mg/kg) 在6-OHDA损伤的大鼠中没有产生任何统计学上显著的异常运动症状[1]。在小鼠和大鼠的氟哌啶醇诱导的低运动模型中，vipadenant 的最小有效剂量分别为0.1 和1 mg/kg。Vipadenant (3 和10 mg/kg, p.o.) 能够增加6-OHDA 损伤大鼠的对侧旋转[2]。 |
| Synonyms | 地瑞那韦, 达芦那韦, TMC114 |
| molecular weight | 547.66 |
| Molecular formula | C27H37N3O7S |
| CAS | 206361-99-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 35 mg/mL (78.14 mM) |
| References | 1. Fujimoto H, et al. Biol Pharm Bull, 2009, 32(9), 1588-1593. |