| Description | Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody that targets TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory immune checkpoint responsible for NK cell depletion and diminished cytokine secretion via interaction with CD155. It also modulates effector T cell activity and increases regulatory T cell (Tregs) function, contributing to immunosuppression [1]. |
| Synonyms | M-6223 |
| molecular weight | N/A |
| CAS | 2649362-29-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years | Shipping with blue ice. |