| Description | DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations. |
| molecular weight | 468.46 |
| Molecular formula | C25H20N6O4 |
| CAS | 794466-17-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |