| Description | D75-4590 is a β-1,6-Glucan inhibitor. As glucan is a major component of the cell wall, specifically β-1,6-Glucan, D75-4590 can fight fungal infections by inhibiting its synthetase. |
| In vitro | D75-4590 对包括耐氟康唑菌株在内的多种白假丝酵母菌有活性。大多数C. albicans、C. tropicalis和C. parapsilosis菌株展现了与在三唑类化合物存在时观察到的类似的拖尾生长现象[1]。 |
| molecular weight | 349.47 |
| Molecular formula | C21H27N5 |
| CAS | 384376-42-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 5 mg/mL (14.31 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Akihiro Kitamura, et al. Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. Antimicrob Agents Chemother. 2009 Feb;53(2):670-7. |