D-myo-Inositol-1,4,5-triphosphate trisodium Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	D-myo-Inositol-1,4,5-triphosphate trisodium (Inositol 1,4,5-trisphosphate trisodium) is a second messenger produced in cells by phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate. D-myo-Inositol-1,4,5-triphosphate trisodium binds to Ins(1,4,5)P3 receptor binding results in the opening of calcium channels and an increase in intracellular calcium.
In vitro	The dissociation constant (KD) for D-myo-Inositol-1,4,5-trisphosphate (As an inositol phosphate derivative) complexed with Pr55Gag is 2170 μM. The binding affinities of D-myo-Inositol-1,4,5-trisphosphate for matrix (MA) with KD=568 μM.[4]
Synonyms	Inositol 1,4,5-trisphosphate trisodium, Ins(1,4,5)-P3 trisodium, D-myo-Inositol-1,4,5-triphosphate (sodium salt), Ins(1,4,5)P3
molecular weight	489.06
Molecular formula	C6H15Na3O15P3
CAS	141611-10-1
Storage	store at low temperature　\|　Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	PBS (pH 7.2): 50 mg/mL
References	1. Streb H, et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature. 1983;306(5938):67-69. 2. Yoshida Y, et al. Structure and function of inositol 1,4,5-trisphosphate receptor. Jpn J Pharmacol. 1997;74(2):125-137. 3. Exton JH. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol. 1996;36:481-509. 4. Anraku K, et al. Highly sensitive analysis of the interaction between HIV-1 Gag and phosphoinositide derivatives based on surface plasmon resonance. Biochemistry. 2010;49(25):5109-5116.

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D-myo-Inositol-1,4,5-triphosphate trisodium

CAS No.: 141611-10-1