| Description | D-JBD19 is a non-permeable peptide with neuroprotective effects. |
| In vitro | D-JBD19 is a non-permeable peptide corresponding to dJNKi peptide [1]. |
| In vivo | As compared with D-JNKI1, neuroprotective effects of D-JBD19 against middle cerebral artery occlusion. 15.7 ng of either D-JBD19 or D-JNKI1 or 1570 ng of D-JBD19 are injected i.c.v. just after the ischemia. Animals were killed 24 h later. 100 times more D-JBD19 is needed to provide protection than with D-JNKI1 [2]. |
| molecular weight | 2250.597 |
| Molecular formula | C99H164N32O28 |
| CAS | 954134-42-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Cardozo AK, et al. Cell-permeable peptides induce dose- and length-dependent cytotoxic effects. Biochim Biophys Acta. 2007 Sep;1768(9):2222-34. 2. Vaslin A, et al. Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor. J Neurochem. 2011 Dec;119(6):1243-52. |