| Description | CYT296 is a chromatin de-condensation agent that enhances the efficiency of induced pluripotent stem cell (iPSC) generation mediated by defined factors (OSKM) and promotes an open chromatin state in Mouse Embryonic Fibroblast (MEFs), aiding in somatic cell reprogramming. This compound has potential applications in cell replacement therapies and drug screening research [1]. |
| In vitro | CYT296（250nM，72小时）通过改变MEFs的染色质结构，降低了Yamanaka因子的接近障碍，并加速了细胞重编程过程[1]。此外，该化合物能有效干扰MEFs中异染色质的组装，进而显著提高iPSCs的产生率[1]。 |
| In vivo | CYT296 (10-15个4F-和2F-iPSC克隆，皮下注射，一次) 在NOD-SCID小鼠体内诱导产生的iPSCs，展现出多能性特征[1]。 |
| molecular weight | 296.38 |
| Molecular formula | C18H16O2S |
| CAS | 1799392-31-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |