| Description | Cystathionine-γ-lyase-IN-1 (SHIP-2a) is a selective inhibitor of cystathionine γ-lyase (CSE) enzyme (IC50= 6.3 μM). |
| In vitro | Cystathionine-γ-lyase-IN-1 (100 μM) completely abrogates L-cysteine-induced vasorelaxation. Cystathionine-γ-lyase-IN-1 (100 μM; 30 minutes) significantly inhibits the increased H2S production stimulated by L-cysteine in mouse aorta homogenates[1]. |
| Synonyms | SHIP-2a |
| molecular weight | 184.22 |
| Molecular formula | C7H8N2O2S |
| CAS | 2165706-30-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (298.56 mM), Sonication is recommended. Ethanol: 8.1 mg/mL (44.0 mM), Sonication and heating are recommended. |
| References | 1. Angela Corvino, et al. Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci Rep. 2016 Oct 6;6:34398. |