| Description | CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with IC50 value of 19 nM. |
| In vitro | SF-11 is a selective brain-permeable NPY Y2 receptor antagonist with IC50 value of 190 nM. A systematic study of the SAR of the hit molecule SF-11 can identify a selective and highly effective small molecule NPY Y2 receptor antagonist CYM 9484 . CYM 9484 is ten times more effective than the hit molecule SF-11. CYM 9484 is prepared by coupling α, α-diphenylpiperidino-4-methanol with various aryl isothiocyanates. |
| Target activity | NPYY2 receptor:19 nM |
| molecular weight | 509.68 |
| Molecular formula | C27H31N3O3S2 |
| CAS | 1383478-94-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Mittapalli GK, et al. Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3916-20. |