| Description | CYM-5478 is a potent and selective S1P2 agonist. Under nutrient-deprivation stress produced by serum-starvation, CYM-5478 induced a significant increase in the viability of C6 cells in a dose dependent manner at concentrations above 100 nM. |
| Target activity | S1PR3:1950 nM (EC50), S1PR4:>10 μM (EC50), S1PR2:119 nM (EC50), S1PR1:1690 nM (EC50), S1PR5:>10 μM (IC50) |
| Synonyms | CYM 5478, CYM5478 |
| molecular weight | 388.38 |
| Molecular formula | C21H19F3N2O2 |
| CAS | 870762-83-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Deron R. Herr, Marie J. Y. Reolo, Yee Xin Peh, Wei Wang, Chang-Wook Lee, Rich Rivera, Ian C. Paterson & Jerold Chun. Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy. Scientific Reports 6, Article number: 24541 (2016) doi:10.1038/srep24541. |