| Description | Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way. |
| In vitro | Cyclotriazadisulfonamide hydrochloride 在 MO-DC 细胞中对 CD4 的 EC50 为 0.4 μg/mL。Cyclotriazadisulfonamide hydrochloride (10 μg/mL) 能够使细胞表面 CD4 的表达下降 83%。此外，Cyclotriazadisulfonamide hydrochloride 能够有效预防 MT-4 细胞受 HIV-1 和 SIV 的感染，其 EC50 分别为 0.7 和 1.2 g/ml。Cyclotriazadisulfonamide hydrochloride 显著减少了 HIV 主要受体——细胞表面 CD4 的数量，而对检测到的其他细胞受体表达无显著影响[1]。 |
| Synonyms | Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base) |
| molecular weight | 618.25 |
| Molecular formula | C31H40ClN3O4S2 |
| CAS | 392287-03-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Victor Van Puyenbroeck, et al. Preprotein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide. Traffic. 2020 Feb;21(2):250-264. 2. Kurt Vermeire, et al. CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor. Curr HIV Res. 2008 May;6(3):246-56. |
Cyclotriazadisulfonamide hydrochloride
CAS No.: 392287-03-5
Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translatio
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