PeptideDB

Cyclophostin

CAS No.: 144773-26-2

Cyclophostin is an irreversible inhibitor of acetylcholinesterase (AChE).
Sales Email:peptidedb@qq.com

This product is for research use only, not for human use. We do not sell to patients.

Description Cyclophostin is an irreversible inhibitor of acetylcholinesterase (AChE).
molecular weight 234.14
Molecular formula C8H11O6P
CAS 144773-26-2
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Viljoen A, Richard M, Nguyen PC, Fourquet P, Camoin L, Paudal RR, Gnawali GR, Spilling CD, Cavalier JF, Canaan S, Blaise M, Kremer L. Cyclipostins and Cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo. J Biol Chem. 2018 Jan 4. pii: jbc.RA117.000760. doi: 10.1074/jbc.RA117.000760. [Epub ahead of print] PubMed PMID: 29301937. 2. Nguyen PC, Madani A, Santucci P, Martin BP, Paudel RR, Delattre S, Herrmann JL, Spilling CD, Kremer L, Canaan S, Cavalier JF. Cyclophostin and cyclipostins analogs, new promising molecules to treat mycobacterial-related diseases. Int J Antimicrob Agents. 2017 Dec 11. pii: S0924-8579(17)30435-1. doi: 10.1016/j.ijantimicag.2017.12.001. [Epub ahead of print] PubMed PMID: 29241819. 3. Nguyen PC, Delorme V, Bénarouche A, Martin BP, Paudel R, Gnawali GR, Madani A, Puppo R, Landry V, Kremer L, Brodin P, Spilling CD, Cavalier JF, Canaan S. Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. Sci Rep. 2017 Sep 18;7(1):11751. doi: 10.1038/s41598-017-11843-4. PubMed PMID: 28924204; PubMed Central PMCID: PMC5603573. 4. Martin BP, Vasilieva E, Dupureur CM, Spilling CD. Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin. Bioorg Med Chem. 2015 Dec 15;23(24):7529-34. doi: 10.1016/j.bmc.2015.10.044. Epub 2015 Oct 30. PubMed PMID: 26585276.