| Description | Cyclopenthiazide (Cyclomethiazide) is a thiazide diuretic used to treat hypertension and heart failure. It decreases the excretion of calcium ions and uric acid and increases the excretion of sodium and potassium ions. |
| In vivo | Cyclopenthiazide 125 micrograms, a dose lower than is currently marketed, produced a similar hypotensive response to 500 micrograms of the drug without upsetting the biochemical profile[3]. |
| Synonyms | Cyclomethiazide, Su-8341, SU 8341, 环戊噻嗪 |
| molecular weight | 379.88 |
| Molecular formula | C13H18ClN3O4S2 |
| CAS | 742-20-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (118.46 mM) H2O: Insoluble |
| References | 1. Krum H, Jackson B, Conway EL, Howes LG, Johnston CI, Louis WJ. Steady-state pharmacokinetics and pharmacodynamics of cilazapril in the presence and absence of cyclopenthiazide. J Cardiovasc Pharmacol. 1992 Sep;20(3):451-7. PubMed PMID: 1279292. 2. Passmore AP, Whitehead EM, Crawford V, McVeigh GE, Johnston GD. The antihypertensive and metabolic effects of low and conventional dose cyclopenthiazide in type II diabetics with hypertension. Q J Med. 1991 Nov;81(295):919-28. PubMed PMID: 1808632. 3. Mcveigh G E , Galloway D B , Johnston D . The case for low dose diuretics in hypertension: Comparison of low and conventional doses of cyclopenthiazide[J]. BMJ Clinical Research, 1988, 297(6641):95-98. 4. Allman S, Norris RJ. An open, parallel group study comparing a frusemide/amiloride diuretic and a diuretic containing cyclopenthiazide with sustained release potassium in the treatment of congestive cardiac failure--a multicentre general practice study. J Int Med Res. 1990;18 Suppl 2:17B-23B. PubMed PMID: 2193840. |