| Description | Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8] |
| In vitro | In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with isoproterenol , and treatment with this metabolite at 100 μM under heat stress conditions induces the release of oxytocin from the mouse hypothalamus.[9],[4] |
| Synonyms | cADP-Ribose, cADPR, Cyclic ADP-Ribose (ammonium salt) |
| molecular weight | N/A |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: Soluble |
| References | 1. Lee, H.C., Walseth, T.F., Bratt, G.T., et al. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+ -mobilizing activity. J. Biol. Chem. 264(3), 1608-1615 (1989). |