| Description | Cyclandelate (BS 572), a direct-acting smooth muscle relaxant, is used to dilate blood vessels. |
| In vivo | 在血管平滑肌中,Cyclandelate通过钙离子通道拮抗作用,使周围血管扩张。Cyclandelate使芳香族和脂族酯水解,参与异生素的解毒以及酯类和酰胺类前药的活化,但对酰胺或脂肪酰基CoA酯无催化活性。 |
| Synonyms | 安脉生, BS 572, 环扁桃酯, 3,5,5-Trimethylcyclohexyl mandelate |
| molecular weight | 276.37 |
| Molecular formula | C17H24O3 |
| CAS | 456-59-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 51 mg/mL (184.5 mM) DMSO: 55 mg/mL (199 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Middleton B, et al. Drugs, 1987, 33 Suppl 2:75-9. 2. Heffron F, et al. Biochem Pharmacol, 1990, 39(3), 575-580. |