| Description | CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer. |
| In vitro | 在 A549 细胞中，CUR5g（以0、1、5、10、20 和 40 μM的浓度；分别在3、6、12和 24 小时后观察）能诱导广泛的细胞质空泡化，并且 GFP-LC3B 信号从弥漫的细胞质染色转变为斑点状模式，勾勒出自噬体的轮廓[1]。 |
| In vivo | CUR5g（40 mg/kg）和顺铂（1 mg/kg）通过尾静脉每隔两天注射一次，共 15 天，能够延缓异种移植瘤的生长，而 CUR5g 与顺铂的联合治疗几乎完全抑制了肿瘤生长[1]。 |
| Synonyms | CUR-5g |
| molecular weight | 344.41 |
| Molecular formula | C22H20N2O2 |
| CAS | 1370032-20-4 |
| Storage | store at low temperature | store at -20°C |
| Solubility | DMSO: 40 mg/mL (116.14 mM), Sonication is recommended. |
| References | 1. Chen J, et al. CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer. Cell Death Discov. 2022 Oct 31;8(1):435. |