| Description | CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9). |
| In vitro | CU-CPT17e 具有同时激活TLRs 3、8和9的能力。生化研究表明 CU-CPT17e 在人单核细胞THP-1中能够通过诱导多种细胞因子的产生而引发强烈免疫反应。此外，CU-CPT17e通过触发凋亡并在S期阻止细胞周期的进程，抑制了HeLa癌细胞的增殖。这些结果表明 CU-CPT17e 在疫苗佐剂和基于多TLR激活的抗癌疗法中具有应用前景。 |
| molecular weight | 504.49 |
| Molecular formula | C27H24N2O8 |
| CAS | 2109805-75-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2 mg/mL (3.96 mM), Sonication is recommended. |
| References | 1. Zhang L, et al. Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities. J Med Chem. 2017 Jun 22;60(12):5029-5044. |