| Description | CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM) |
| In vivo | CU-CPT8m decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis. |
| Target activity | TLR8:67 nM |
| Synonyms | TLR8-specific antagonist |
| molecular weight | 252.27 |
| Molecular formula | C14H12N4O |
| CAS | 125079-83-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (118.92 mM) |
| References | 1. Zhang S , Hu Z , Tanji H , et al. Small-molecule inhibition of TLR8 through stabilization of its resting state[J]. Nature Chemical Biology, 2017, 14(1):58-64. |