| Description | CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD107 exhibited coagonist activity in the presence of ssRNA, while CU-CPD107 alone could not affect TLR8 signal transduction. |
| In vitro | CU-CPD107 behaved an agonist in the presence of ssRNA in HEK-Blue hTLR8 cells, resulting in a fivefold activation at 100 μΜ by SEAP assay relative to the control. Crucially, CU-CPD107 displayed no agonistic potential in the absence of ssRNA[1]. |
| Target activity | TLR8 (HEK-Blue hTLR8 cells):13.7 μM |
| Synonyms | CU-CPD107 |
| molecular weight | 400.25 |
| Molecular formula | C16H21IN2O2 |
| CAS | 2573912-32-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1.8 mg/mL (4.5 mM) |
| References | 1. Yang Y, et al. Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists. Nat Commun. 2021 Jul 16;12(1):4351. |